Sfoglia per Autore "Pombo-Suarez, M."
Items 1-2 di 2
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Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes
Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ... -
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis
Rodriguez-Lopez, J.; Mustafa, Z.; Pombo-Suarez, M.; Malizos, K. N.; Rego, I.; Blanco, F. J.; Tsezou, A.; Loughlin, J.; Gomez-Reino, J. J.; Gonzalez, A. (2008)Objective. Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ...